Losing B cell identity
- Author(s)
- Carotta, S; Nutt, SL;
- Details
- Publication Year 2008-03,Volume 30,Issue #3,Page 203-207
- Journal Title
- BIOESSAYS
- Publication Type
- Journal Article
- Abstract
- The transcription factor Pax5 is essential for the initial commitment of hematopoietic progenitors to the B cell lineage. Recently, our understanding of the lineage commitment process has been extended with the finding that Pax5 is also continuously required throughout B cell development to reinforce commitment, as inactivation of Pax5in mature B cells results in their de-differentiation to a progenitor stage that is capable of multi-lineage potential.((1)) The reliance of B cell identity on a single gene is not without its problems as the loss of Pax5 results in B cell malignancies in mouse models and mutation in human PAX5 is the most-common genetic lesion in acute lymphoblastic leukemia.
- Publisher
- WILEY-BLACKWELL
- Keywords
- TRANSCRIPTION FACTOR PAX5; HEMATOPOIETIC STEM-CELL; LINEAGE COMMITMENT; DEFINED FACTORS; DIFFERENTIATION; INDUCTION; GENE; LYMPHOPOIESIS; FIBROBLASTS; MACROPHAGES
- Publisher's Version
- https://doi.org/10.1002/bies.20725
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-03-01 12:00:00