Neuropeptide Y receptor-specifically modulates human neutrophil function
- Author(s)
- Bedoui, S; Kromer, A; Gebhardt, T; Jacobs, R; Raber, K; Dimitrijevic, M; Heine, J; von Horsten, S;
- Details
- Publication Year 2008-03,Volume 195,Issue #1-2,Page 88-95
- Journal Title
- JOURNAL OF NEUROIMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Despite a continuously growing body of evidence highlighting the role of NPY in the immune system, surprisingly little is known about its ability to alter human leukocyte function. We therefore set out to examine NPY receptor expression and functional effects of NPY in freshly isolated human neutrophils. Our results not only demonstrate for the first time the presence of specific NPY receptors on human neutrophils, but also unveil of how these receptors differentially modulate critical functions of neutrophils such as phagocytosis of bacteria as well as the release of reactive oxygen species. (C) 2008 Elsevier B.V. All rights reserved.
- Publisher
- ELSEVIER SCIENCE BV
- Keywords
- IN-VIVO; PANCREATIC-POLYPEPTIDE; SYMPATHETIC-NERVE; IMMUNE-SYSTEM; PEPTIDE-YY; NPY; ACTIVATION; MONOCYTES; SHOCK; MOBILIZATION
- Publisher's Version
- https://doi.org/10.1016/j.jneuroim.2008.01.012
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-03-01 12:00:00