Small-sample estimation of negative binomial dispersion, with applications to SAGE data
Author(s)
Robinson, MD; Smyth, GK;
Details
Publication Year 2008-04,Volume 9,Issue #2,Page 321-332
Journal Title
BIOSTATISTICS
Publication Type
Journal Article
Abstract
We derive a quantile-adjusted conditional maximum likelihood estimator for the dispersion parameter of the negative binomial distribution and compare its performance, in terms of bias, to various other methods. Our estimation scheme outperforms all other methods in very small samples, typical of those from serial analysis of gene expression studies, the motivating data for this study. The impact of dispersion estimation on hypothesis testing is studied. We derive an "exact" test that outperforms the standard approximate asymptotic tests.
Publisher
OXFORD UNIV PRESS
Keywords
GENE-EXPRESSION; QUASI-LIKELIHOOD; SERIAL ANALYSIS; PARAMETER; PROFILES; MODELS
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-04-01 12:00:00
An error has occurred. This application may no longer respond until reloaded. Reload 🗙