Small-sample estimation of negative binomial dispersion, with applications to SAGE data
- Author(s)
- Robinson, MD; Smyth, GK;
- Details
- Publication Year 2008-04,Volume 9,Issue #2,Page 321-332
- Journal Title
- BIOSTATISTICS
- Publication Type
- Journal Article
- Abstract
- We derive a quantile-adjusted conditional maximum likelihood estimator for the dispersion parameter of the negative binomial distribution and compare its performance, in terms of bias, to various other methods. Our estimation scheme outperforms all other methods in very small samples, typical of those from serial analysis of gene expression studies, the motivating data for this study. The impact of dispersion estimation on hypothesis testing is studied. We derive an "exact" test that outperforms the standard approximate asymptotic tests.
- Publisher
- OXFORD UNIV PRESS
- Keywords
- GENE-EXPRESSION; QUASI-LIKELIHOOD; SERIAL ANALYSIS; PARAMETER; PROFILES; MODELS
- Publisher's Version
- https://doi.org/10.1093/biostatistics/kxm030
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-04-01 12:00:00