Macrophages, more than just scavengers: Their role in breast development and cancer
- Author(s)
- Gyorki, DE; Lindeman, GJ;
- Details
- Publication Year 2008-06,Volume 78,Issue #6,Page 432-436
- Journal Title
- ANZ JOURNAL OF SURGERY
- Publication Type
- Journal Article
- Abstract
- Macrophages, derived from circulating monocytes, are located within virtually all adult tissues. There, these specialized cells adopt tissue-specific functions that are important for normal tissue homeostasis and response to physiological challenges. Increasing evidence suggests that macrophages play a role in the normal development of certain organs, such as the breast. Intriguingly, macrophages are often found in the stroma of breast tumours, where they may promote tumour growth and metastasis. In this review we discuss this emerging area of developmental and tumour biology.
- Publisher
- WILEY-BLACKWELL
- Keywords
- COLONY-STIMULATING FACTOR; MAMMARY-GLAND DEVELOPMENT; TUMOR-ASSOCIATED MACROPHAGES; ENDOTHELIAL GROWTH-FACTOR; STEM-CELLS; POOR-PROGNOSIS; FACTOR-I; ANGIOGENESIS; CARCINOMA; EXPRESSION
- Publisher's Version
- https://doi.org/10.1111/j.1445-2197.2008.04531.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-06-01 12:00:00