Sheepish B cells: evidence for antigen-independent antibody diversification in humans and mice

Author(s): Tarlinton, D;
Details: Publication Year 2008-06-09,Volume 205,Issue #6,Page 1251-1254
Journal Title: JOURNAL OF EXPERIMENTAL MEDICINE
Publication Type: Journal Article
Abstract: Antibody diversity is first generated by rearrangement of immunoglobulin (Ig) genes during B cell development in the bone marrow, and later by antigen-driven diversification in germinal centers (GCs). New data in humans and mice now identify specific B cell populations that may have undergone antigen-independent hypermutation outside GCs.
Publisher: ROCKEFELLER UNIV PRESS
Keywords: SPLENIC MARGINAL ZONE; IMMUNOGLOBULIN REPERTOIRE; GENE CONVERSION; MEMORY; SUBSETS; HYPERMUTATION; SELECTION
Publisher's Version: https://doi.org/10.1084/jem.20081057
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2008-06-09 12:00:00