Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoinimunity
Details
Publication Year 2008-05-01,Volume 180,Issue #9,Page 5789-5793
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
Naive and memory T cells show differences in their response to antigenic stimulation. We examined whether this difference extended to the peripheral deletion of T cells reactive to self-Ag or, alternatively, the induction of autoimmunity. Our results show that although both populations where susceptible to deletion, memory T cells, but not naive T cells, also gave rise to autoimmunity after in vivo presentation of skin-derived self-Ags. The same migratory dendritic cells presented self-Ag to both naive and memory T cell populations, but only the latter had significant levels of the effector molecule granzyme B. Memory T cells also expressed increased levels of the high affinity IL-2 receptor chain after self-Ag recognition. Provision of IL-2 signaling using a stimulatory complex of anti-IL-2 Ab and IL-2 drove the otherwise tolerant naive T cells toward an autoimmune response. Therefore, enhanced IL-2 signaling can act as a major selector between tolerance and autoimmunity.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
RESTRICTED CROSS-PRESENTATION; PERIPHERAL TOLERANCE; DENDRITIC CELLS; MEMORY; ANTIGENS; INTERLEUKIN-2; EFFECTOR; STIMULATION; INDUCTION; KINETICS
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2008-05-01 12:00:00
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