Cutting edge: Enhanced IL-2 signaling can convert self-specific T cell response from tolerance to autoinimunity
- Author(s)
- Waithman, J; Gebhardt, T; Davey, GM; Heath, WR; Carbone, FR;
- Details
- Publication Year 2008-05-01,Volume 180,Issue #9,Page 5789-5793
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Naive and memory T cells show differences in their response to antigenic stimulation. We examined whether this difference extended to the peripheral deletion of T cells reactive to self-Ag or, alternatively, the induction of autoimmunity. Our results show that although both populations where susceptible to deletion, memory T cells, but not naive T cells, also gave rise to autoimmunity after in vivo presentation of skin-derived self-Ags. The same migratory dendritic cells presented self-Ag to both naive and memory T cell populations, but only the latter had significant levels of the effector molecule granzyme B. Memory T cells also expressed increased levels of the high affinity IL-2 receptor chain after self-Ag recognition. Provision of IL-2 signaling using a stimulatory complex of anti-IL-2 Ab and IL-2 drove the otherwise tolerant naive T cells toward an autoimmune response. Therefore, enhanced IL-2 signaling can act as a major selector between tolerance and autoimmunity.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- RESTRICTED CROSS-PRESENTATION; PERIPHERAL TOLERANCE; DENDRITIC CELLS; MEMORY; ANTIGENS; INTERLEUKIN-2; EFFECTOR; STIMULATION; INDUCTION; KINETICS
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2008-05-01 12:00:00