Genome analysis of the platypus reveals unique signatures of evolution

Warren, WC; Hillier, LW; Graves, JAM; Birney, E; Ponting, CP; Grutzner, F; Belov, K; Miller, W; Clarke, L; Chinwalla, AT; Yang, SP; Heger, A; Locke, DP; Miethke, P; Waters, PD; Veyrunes, F; Fulton, L; Fulton, B; Graves, T; Wallis, J; Puente, XS; Lopez-Otin, C; Ordonez, GR; Eichler, EE; Chen, L; Cheng, Z; Deakin, JE; Alsop, A; Thompson, K; Kirby, P; Papenfuss, AT; Wakefield, MJ; Olender, T; Lancet, D; Huttley, GA; Smit, AFA; Pask, A; Temple-Smith, P; Batzer, MA; Walker, JA; Konkel, MK; Harris, RS; Whittington, CM; Wong, ESW; Gemmell, NJ; Buschiazzo, E; Jentzsch, IMV; Merkel, A; Schmitz, J; Zemann, A; Churakov, G; Kriegs, JO; Brosius, J; Murchison, EP; Sachidanandam, R; Smith, C; Hannon, GJ; Tsend-Ayush, E; McMillan, D; Attenborough, R; Rens, W; Ferguson-Smith, M; Lefevre, CM; Sharp, JA; Nicholas, KR; Ray, DA; Kube, M; Reinhardt, R; Pringle, TH; Taylor, J; Jones, RC; Nixon, B; Dacheux, JL; Niwa, H; Sekita, Y; Huang, XQ; Stark, A; Kheradpour, P; Kellis, M; Flicek, P; Chen, Y; Webber, C; Hardison, R; Nelson, J; Hallsworth-Pepin, K; Delehaunty, K; Markovic, C; Minx, P; Feng, YC; Kremitzki, C; Mitreva, M; Glasscock, J; Wylie, T; Wohldmann, P; Thiru, P; Nhan, MN; Pohl, CS; Smith, SM; Hou, SF; Renfree, MB; Mardis, ER; Wilson, RK

Author(s): Warren, WC; Hillier, LW; Graves, JAM; Birney, E; Ponting, CP; Grutzner, F; Belov, K; Miller, W; Clarke, L; Chinwalla, AT; Yang, SP; Heger, A; Locke, DP; Miethke, P; Waters, PD; Veyrunes, F; Fulton, L; Fulton, B; Graves, T; Wallis, J; Puente, XS; Lopez-Otin, C; Ordonez, GR; Eichler, EE; Chen, L; Cheng, Z; Deakin, JE; Alsop, A; Thompson, K; Kirby, P; Papenfuss, AT; Wakefield, MJ; Olender, T; Lancet, D; Huttley, GA; Smit, AFA; Pask, A; Temple-Smith, P; Batzer, MA; Walker, JA; Konkel, MK; Harris, RS; Whittington, CM; Wong, ESW; Gemmell, NJ; Buschiazzo, E; Jentzsch, IMV; Merkel, A; Schmitz, J; Zemann, A; Churakov, G; Kriegs, JO; Brosius, J; Murchison, EP; Sachidanandam, R; Smith, C; Hannon, GJ; Tsend-Ayush, E; McMillan, D; Attenborough, R; Rens, W; Ferguson-Smith, M; Lefevre, CM; Sharp, JA; Nicholas, KR; Ray, DA; Kube, M; Reinhardt, R; Pringle, TH; Taylor, J; Jones, RC; Nixon, B; Dacheux, JL; Niwa, H; Sekita, Y; Huang, XQ; Stark, A; Kheradpour, P; Kellis, M; Flicek, P; Chen, Y; Webber, C; Hardison, R; Nelson, J; Hallsworth-Pepin, K; Delehaunty, K; Markovic, C; Minx, P; Feng, YC; Kremitzki, C; Mitreva, M; Glasscock, J; Wylie, T; Wohldmann, P; Thiru, P; Nhan, MN; Pohl, CS; Smith, SM; Hou, SF; Renfree, MB; Mardis, ER; Wilson, RK;
Details: Publication Year 2008-05-08,Volume 453,Issue #7192,Page 175-183
Journal Title: NATURE
Publication Type: Journal Article
Abstract: We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co- opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non- protein- coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.
Publisher: NATURE PUBLISHING GROUP
Keywords: SMALL NUCLEOLAR RNAS; ORNITHORHYNCHUS-ANATINUS; ANTIMICROBIAL PEPTIDES; MONODELPHIS-DOMESTICA; PHYLOGENETIC ANALYSIS; VERTEBRATE EVOLUTION; DNA-SEQUENCES; IMMUNE-SYSTEM; GENE-CLUSTER; MONOTREME
Research Division(s): Bioinformatics
Publisher's Version: https://doi.org/10.1038/nature06936
Open Access at Publisher's Site: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2803040/

Creation Date: 2008-05-08 12:00:00