Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy
- Author(s)
- Dent, A; Malhotra, I; Mungai, P; Muchiri, E; Crabb, BS; Kazura, JW; King, CL;
- Details
- Publication Year 2006-11-15,Volume 177,Issue #10,Page 7139-7145
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- African infants are often born of mothers infected with malaria during pregnancy. This can result in fetal exposure to malaria-infected erythrocytes or their soluble products with subsequent fetal immune priming or tolerance in utero. We performed a cohort study of 30 newborns from a malaria holoendemic area of Kenya to determine whether T cell sensitization to Plasinodium falciparum merozoite surface protein-1 (MSP-1) at birth correlates with infant development of anti-MSP-1 Abs acquired as a consequence of natural malaria infection. Abs to the 42- and 19-kDa C-terminal processed fragments of MSP-1 were determined by serology and by a functional assay that quantifies invasion inhibition Abs against the MSP-1,9 merozoite ligand (MSP-1(19) IIA). Infants had detectable IgG and IgM Abs to MSP-1(42) and MSP-1,9 at 6 mo of age with no significant change by age 24-30 mo. In contrast, MSP-1,9 IIA levels increased from 6 to 24-30 mo of age (16-29%,p < 0.01). Infants with evidence of prenatal exposure to malaria (defined by P. falciparum detection in maternal, placental, and/or cord blood compartments) and T cell sensitization at birth (defined by cord blood lymphocyte cytokine responses to MSP-1) showed the greatest age-related increase in MSP-1,9 IIA compared with infants with prenatal exposure to malaria but who lacked detectable T cell MSP-1 sensitization. These data suggest that fetal sensitization or tolerance to MSP-1, associated with maternal malaria infection during pregnancy, affects the development of functional Ab responses to MSP-1 during infancy.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- TIME QUANTITATIVE PCR; PLACENTAL MALARIA; SERUM ANTIBODIES; PROTECTIVE ROLE; INFECTION; RESPONSES; ANTIGEN; SUSCEPTIBILITY; TRANSMISSION; MORBIDITY
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Creation Date: 2006-11-15 12:00:00