Prenatal malaria immune experience affects acquisition of Plasmodium falciparum merozoite surface protein-1 invasion inhibitory antibodies during infancy
Details
Publication Year 2006-11-15,Volume 177,Issue #10,Page 7139-7145
Journal Title
JOURNAL OF IMMUNOLOGY
Publication Type
Journal Article
Abstract
African infants are often born of mothers infected with malaria during pregnancy. This can result in fetal exposure to malaria-infected erythrocytes or their soluble products with subsequent fetal immune priming or tolerance in utero. We performed a cohort study of 30 newborns from a malaria holoendemic area of Kenya to determine whether T cell sensitization to Plasinodium falciparum merozoite surface protein-1 (MSP-1) at birth correlates with infant development of anti-MSP-1 Abs acquired as a consequence of natural malaria infection. Abs to the 42- and 19-kDa C-terminal processed fragments of MSP-1 were determined by serology and by a functional assay that quantifies invasion inhibition Abs against the MSP-1,9 merozoite ligand (MSP-1(19) IIA). Infants had detectable IgG and IgM Abs to MSP-1(42) and MSP-1,9 at 6 mo of age with no significant change by age 24-30 mo. In contrast, MSP-1,9 IIA levels increased from 6 to 24-30 mo of age (16-29%,p < 0.01). Infants with evidence of prenatal exposure to malaria (defined by P. falciparum detection in maternal, placental, and/or cord blood compartments) and T cell sensitization at birth (defined by cord blood lymphocyte cytokine responses to MSP-1) showed the greatest age-related increase in MSP-1,9 IIA compared with infants with prenatal exposure to malaria but who lacked detectable T cell MSP-1 sensitization. These data suggest that fetal sensitization or tolerance to MSP-1, associated with maternal malaria infection during pregnancy, affects the development of functional Ab responses to MSP-1 during infancy.
Publisher
AMER ASSOC IMMUNOLOGISTS
Keywords
TIME QUANTITATIVE PCR; PLACENTAL MALARIA; SERUM ANTIBODIES; PROTECTIVE ROLE; INFECTION; RESPONSES; ANTIGEN; SUSCEPTIBILITY; TRANSMISSION; MORBIDITY
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Creation Date: 2006-11-15 12:00:00
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