Conotoxins down under
- Author(s)
- Norton, RS; Olivera, BM;
- Details
- Publication Year 2006-12-01,Volume 48,Issue #7,Page 780-798
- Journal Title
- TOXICON
- Publication Type
- Journal Article
- Abstract
- In the four decades since toxinologists in Australia and elsewhere started to investigate the active constituents of venomous cone snails, a wealth of information has emerged on the various classes of peptides and proteins that make their venoms such potent bioactive cocktails. This article provides an overview of the current state of knowledge of these venom constituents, several of which are of interest as potential human therapeutics as a consequence of their high potency and exquisite target specificity. With the promise of as many as 50,000 venom components across the entire Conus genus, many more interesting peptides can be anticipated. (c) 2006 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- NICOTINIC ACETYLCHOLINE-RECEPTOR; METHYL-D-ASPARTATE; 3-DIMENSIONAL SOLUTION STRUCTURE; RESISTANT SODIUM-CHANNELS; AMINO-ACID SUBSTITUTIONS; CONUS-PURPURASCENS VENOM; NEURONAL NA+ CHANNELS; MARINE SNAIL CONUS; SHAKER K+ CHANNELS; GATED ION-CHANNEL
- Publisher's Version
- https://doi.org/10.1016/j.toxicon.2006.07.022
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-12-01 12:00:00