Unravelling the complexities of the NF-kappa B signalling pathway using mouse knockout and transgenic models
- Author(s)
- Gerondakis, S; Grumont, R; Gugasyan, R; Wong, L; Isomura, I; Ho, W; Banerjee, A;
- Details
- Publication Year 2006-10-30,Volume 25,Issue #51,Page 6781-6799
- Journal Title
- ONCOGENE
- Publication Type
- Journal Article
- Abstract
- The nuclear factor-kappa B (NF-kappa B) signalling pathway serves a crucial role in regulating the transcriptional responses of physiological processes that include cell division, cell survival, differentiation, immunity and inflammation. Here we outline studies using mouse models in which the core components of the NF-kappa B pathway, namely the I kappa B kinase subunits (IKK alpha, IKK beta and NEMO), the I kappa B ;proteins (I kappa B alpha, I kappa B beta, I kappa B epsilon and Bcl-3) and the five NF-kappa B transcription factors (NF-kappa B1, NF-kappa B2, c-Rel, RelA and RelB), have been genetically manipulated using transgenic and knock out technology.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- REL TRANSCRIPTION FACTORS; CELL-INTRINSIC EXPRESSION; SEVERE LIVER DEGENERATION; GERMINAL CENTER REACTIONS; T-LYMPHOCYTE DEVELOPMENT; GAMMA-DEFICIENT MICE; C-H TRANSCRIPTION; IKK-ALPHA; IN-VIVO; TOXOPLASMA-GONDII
- Publisher's Version
- https://doi.org/10.1038/sj.onc.1209944
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-10-30 12:00:00