Normalization of boutique two-color microarrays with a high proportion of differentially expressed probes
Publication Year 2007, Volume 8, Issue #1, Page -
- Journal Title
- GENOME BIOLOGY
- Publication Type
- Journal Article
- Normalization is critical for removing systematic variation from microarray data. For two-color microarray platforms, intensity-dependent lowess normalization is commonly used to correct relative gene expression values for biases. Here we outline a normalization method for use when the assumptions of lowess normalization fail. Specifically, this can occur when specialized boutique arrays are constructed that contain a subset of genes selected to test particular biological functions.
- BIOMED CENTRAL LTD
- CDNA MICROARRAY; HOUSEKEEPING GENES
- Publisher's Version
- Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-01-01 12:00:00Last Modified: 0001-01-01 12:00:00