Normalization of boutique two-color microarrays with a high proportion of differentially expressed probes
Details
Publication Year 2007, Volume 8, Issue #1, Page -
Journal Title
GENOME BIOLOGY
Publication Type
Journal Article
Abstract
Normalization is critical for removing systematic variation from microarray data. For two-color microarray platforms, intensity-dependent lowess normalization is commonly used to correct relative gene expression values for biases. Here we outline a normalization method for use when the assumptions of lowess normalization fail. Specifically, this can occur when specialized boutique arrays are constructed that contain a subset of genes selected to test particular biological functions.
Publisher
BIOMED CENTRAL LTD
Keywords
CDNA MICROARRAY; HOUSEKEEPING GENES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2007-01-01 12:00:00
Last Modified: 0001-01-01 12:00:00
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