CTL response compensation for the loss of an immunodominant class I-restricted HSV-1 determinant
- Author(s)
- Stock, AT; Jones, CM; Heath, WR; Carbone, FR;
- Details
- Publication Year 2006-12,Volume 84,Issue #6,Page 543-550
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- The T-cell response to even complex pathogens is often focused on only a handful of immunodominant determinants. Such narrow responses provoke a selective pressure that can drive the emergence of CTL escape variants, raising the question of whether a broader response, targeting multiple non-dominant peptides may be more beneficial. To examine the ability of the T-cell repertoire to respond to non-dominant determinants, we have investigated how mutating the dominant peptide in HSV affects the magnitude of the CD8(+) T-cell response. We found that the CTL response to HSV lacking the dominant peptide was only modestly reduced compared with the wild-type virus and, surprisingly, this compensation occurred without any enhancement in the response to an established minor epitope. These findings are supportive of a malleable T-cell repertoire that can elicit strong responses to alternate, unknown determinants in the absence of the dominant response.
- Publisher
- BLACKWELL PUBLISHING
- Keywords
- CYTOTOXIC T-LYMPHOCYTES; MINOR HISTOCOMPATIBILITY ANTIGENS; HERPES-SIMPLEX VIRUS-1; CELL COMPETITION; IMMUNE-RESPONSE; INFECTION; EPITOPE; CHORIOMENINGITIS; RECOGNITION; ACTIVATION
- Publisher's Version
- https://doi.org/10.1111/j.1440-1711.2006.01469.x
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-12-01 12:00:00