Mapping of the Plasmodium chabaudi resistance locus char2
- Author(s)
- Lin, E; Pappenfuss, T; Tan, RB; Senyschyn, D; Bahlo, M; Speed, TP; Foote, SJ;
- Details
- Publication Year 2006-10,Volume 74,Issue #10,Page 5814-5819
- Journal Title
- INFECTION AND IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Animals congenic for the char2 host response locus to the murine malarial parasite Plasmodium chabaudi have been bred, and they demonstrated a phenotypic difference from the parental lines. These congenic lines have been crossed back to the parental line to generate recombinants across the congenic intervals. The recombinants were inbred, and the subcongenic intervals were fixed. These lines were then challenged with parasites and assessed as being either resistant or susceptible. From the analysis of many subcongenic lines, it has become obvious that there are at least two loci underlying the char2 locus and that both of these mediate resistance when the haplotype derives from the resistant C57BL/6 strain.
- Publisher
- AMER SOC MICROBIOLOGY
- Keywords
- CHROMOSOME 5Q31-Q33; FALCIPARUM MALARIA; GENETIC-CONTROL; MICE; SUSCEPTIBILITY; PARASITEMIA; TRAIT
- Publisher's Version
- https://doi.org/10.1128/IAI.01690-05
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-10-01 12:00:00