Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
- Author(s)
- Allan, RS; Waithman, J; Bedoui, S; Jones, CM; Villadangos, JA; Zhan, YF; Lew, AM; Shortman, K; Heath, WR; Carbone, FR;
- Details
- Publication Year 2006-07,Volume 25,Issue #1,Page 153-162
- Journal Title
- IMMUNITY
- Publication Type
- Journal Article
- Abstract
- Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here we show that after skin infection with herpes simplex virus (HSV), cytotoxic T lymphocyte (CTL) activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs. Despite a lack of direct presentation by migratory DCs, blocking their egress from infected skin substantially inhibited class I-restricted presentation and HSV-specific CTL responses. These results support the argument for initial transport of antigen by migrating DCs, followed by its transfer to the lymphoid-resident DCs for presentation and CTL priming. Given that relatively robust CTL responses were seen with small numbers of skin-emigrant DCs, we propose that this inter-DC antigen transfer functions to amplify presentation across a larger network of lymphoid-resident DCs for efficient T cell activation.
- Publisher
- CELL PRESS
- Keywords
- HERPES-SIMPLEX-VIRUS; EPIDERMAL LANGERHANS CELLS; CD8(+) T-CELLS; IN-VIVO; CUTTING EDGE; ANTIVIRAL IMMUNITY; CROSS-PRESENTATION; INFECTION; SKIN; ACTIVATION
- Publisher's Version
- https://doi.org/10.1016/j.immuni.2006.04.017
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-07-01 12:00:00