Migratory dendritic cells transfer antigen to a lymph node-resident dendritic cell population for efficient CTL priming
Details
Publication Year 2006-07,Volume 25,Issue #1,Page 153-162
Journal Title
IMMUNITY
Publication Type
Journal Article
Abstract
Skin dendritic cells (DCs) are thought to act as key initiators of local T cell immunity. Here we show that after skin infection with herpes simplex virus (HSV), cytotoxic T lymphocyte (CTL) activation required MHC class I-restricted presentation by nonmigratory CD8(+) DCs rather than skin-derived DCs. Despite a lack of direct presentation by migratory DCs, blocking their egress from infected skin substantially inhibited class I-restricted presentation and HSV-specific CTL responses. These results support the argument for initial transport of antigen by migrating DCs, followed by its transfer to the lymphoid-resident DCs for presentation and CTL priming. Given that relatively robust CTL responses were seen with small numbers of skin-emigrant DCs, we propose that this inter-DC antigen transfer functions to amplify presentation across a larger network of lymphoid-resident DCs for efficient T cell activation.
Publisher
CELL PRESS
Keywords
HERPES-SIMPLEX-VIRUS; EPIDERMAL LANGERHANS CELLS; CD8(+) T-CELLS; IN-VIVO; CUTTING EDGE; ANTIVIRAL IMMUNITY; CROSS-PRESENTATION; INFECTION; SKIN; ACTIVATION
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Creation Date: 2006-07-01 12:00:00
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