CD4+ T cells can protect APC from CTL-mediated elimination
- Author(s)
- Mueller, SN; Jones, CM; Stock, AT; Suter, M; Heath, WR; Carbone, FR;
- Details
- Publication Year 2006-06-15,Volume 176,Issue #12,Page 7379-7384
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Professional APC play a central role in generating antiviral CD8(+) CTL immunity. However, the fate of such APC following interaction with these same CTL remains poorly understood. We have shown previously that prolonged Ag presentation persists in the presence of a strong CTL response following HSV infection. In this study, we examined the mechanism of survival of APC in vivo when presenting an,immunodominant determinant from HSV. We show that transferred peptide-labeled dendritic cells were eliminated from draining lymph nodes in the presence of HSV-specific CTL. Maturation of dendritic cells with LPS or anti-CD40 before injection protected against CTL lysis in vivo. Furthermore, endogenous APC could be eliminated from draining lymph nodes early after HSV infection by adoptive transfer of HSV-specific CTL, yet the cotransfer of significant virus-specific CD4(+) T cell help promoted prolonged Ag presentation. This suggests that Th cells may assist in prolonging class I-restricted Ag presentation, potentially enhancing CTL recruitment and allowing more efficient T cell priming.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- HERPES-SIMPLEX-VIRUS; ANTIGEN-PRESENTING CELLS; DRAINING LYMPH-NODE; DENDRITIC CELLS; IN-VIVO; INDUCED APOPTOSIS; CUTTING EDGE; INFECTION; EXPRESSION; RESPONSES
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Creation Date: 2006-06-15 12:00:00