B-cell memory: are subsets necessary?
- Author(s)
- Tarlinton, D;
- Details
- Publication Year 2006-10,Volume 6,Issue #10,Page 785-790
- Journal Title
- NATURE REVIEWS IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- B-cell memory is provided by populations of quiescent memory B cells and long-lived plasma cells. Whereas it is clear that both of these cell populations arise from germinal centres, the signals and circumstances that trigger germinal-centre B cells to enter and then persist in memory compartments are poorly defined. Here, I propose that germinal centres produce memory B cells and plasma cells throughout the immune response and that memory B cells arise by the emigration of B cells that are chosen at random from the pool available in the germinal centre. The ability of such emigrants to survive as memory B cells depends on their germinal-centre 'history', with the persistence of high-affinity B-cell variants being favoured.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- SECONDARY IMMUNE-RESPONSES; ANTIGEN-CAPTURING CELLS; ANTIBODY-FORMING-CELLS; MARROW PLASMA-CELLS; GERMINAL-CENTERS; CLONAL SELECTION; IMMUNOLOGICAL MEMORY; BLIMP-1 EXPRESSION; SECRETING CELLS; GENE-EXPRESSION
- Publisher's Version
- https://doi.org/10.1038/nri1938
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2006-10-01 12:00:00