Similar functional activity of dendritic cells recruited to the mesenteric lymph nodes of newborn and adult mice after the rectal delivery of Mycobacterium bovis BCG
Details
Publication Year 2006-08,Volume 8,Issue #9-10,Page 2341-2351
Journal Title
MICROBES AND INFECTION
Publication Type
Journal Article
Abstract
BCG rectal administration to newborn and adult mice induced protective immune responses against tuberculosis. BCG reaches the subepithelial site and the draining mesenteric lymph nodes (MLNs), and dendritic cells (DC) could be recruited to these sites. Using polarized Caco-2 epithelial cells, we showed that BCG translocates epithelial cells to basolateral compartment. Delayed in newborn BALB/c mice, an important recruitment of CD11c(+) DCs, was documented in the rectal lamina propria and the MLNs during the first two weeks after rectal BCG delivery. In MLNs, two major DC subtypes were observed: conventional DCs (cDCs) (B220(-)) and plasmacytoid DCs (pDCs) (B220(+)). CIRE, mouse DC-specific intracellular adhesion molecule 3 grabbing non-integrin (DC-SIGN) is predominantly expressed on pDCs and at a higher level on pDCs from the adult compared to newborn MLNs. cDCs with a higher capacity to induce the proliferation of naive CD4(+) T cells than pDCs, triggered CD4(+) T cells to produce interferon-gamma whereas pDCs triggered them to release interleukin-10. Both DC subtypes equilibrates T cells as a source of microbicidal/microbiostatic signals and those acting as source of counter-inflammatory signals, preventing tissue damage and/or accelerating tissue repair. Thus, rectal delivery of BCG could be a safe and efficient route of vaccination against tuberculosis. (c) 2006 Elsevier SAS. All rights reserved.
Publisher
ELSEVIER SCIENCE BV
Keywords
IMMUNE-RESPONSE; PEYERS PATCH; ANTIGEN; INDUCE; DIFFERENTIATION; IMMUNIZATION; PROTECTION; PHENOTYPE; CHEMOKINE; BACTERIA
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Creation Date: 2006-08-01 12:00:00
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