Antigen-induced selective recruitment of circulating lymphocytes (Reprinted from Cellular Immunology, vol 2, pg 171-181, 1971)
- Author(s)
- Sprent, J; Miller, JFAP; Mitchell, GF;
- Details
- Publication Year 2006-08-01,Volume 177,Issue #3,Page 1381-1391
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Thoracic duct lymphocytes obtained from mice 1-2 days after the injection of sheep erythrocytes and injected into thymectomized, irradiated, marrow-protected syngeneic hosts were deficient in adoptively transferring immune reactivity to sheep erythrocytes but normal with respect to horse erythrocytes. Cells collected at 3 days had normal reactivity, but cells collected at 5 days allowed their hosts to produce an enhanced response to sheep erythrocytes and a somewhat depressed response to horse erythrocytes. Thoracic duct lymphocytes obtained from CBA mice 2 days after injection of (CBA x C57BL) F-1 spleen cells produced splenomegaly in newborn (CBA X BALB/c)F-1 mice but not in (CBA x C57BL)F-1 recipients. When obtained 5 days after injection, they caused an increase in the splenic index of the (CBA x C57BL)F, recipients significantly above that given by control lymphocytes from saline-injected donors. These results are interpreted in terms of a selective recruitment from the circulation of specific antigen-sensitive cells, occurring soon after antigen administration and followed in turn by a rapid reentry of such cells into the pool in an increased proportion.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- THORACIC DUCT LYMPHOCYTES; HEMOLYSIN-FORMING CELLS; IMMUNE RESPONSE; LYMPH-NODE; BONE MARROW; THYMUS; RAT; STIMULATION; SPLEEN; OUTPUT
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Creation Date: 2006-08-01 12:00:00