Sequential allocation and global pattern of movement of the definitive endoderm in the mouse embryo during gastrulation
Details
Publication Year 2007-01-15, Volume 134, Issue #2, Page 251-260
Journal Title
DEVELOPMENT
Publication Type
Journal Article
Abstract
During mouse gastrulation, endoderm cells of the dorsal foregut are recruited ahead of the ventral foregut and move to the anterior region of the embryo via different routes. Precursors of the anterior-most part of the foregut and those of the mid- and hind-gut are allocated to the endoderm of the mid-streak-stage embryo, whereas the precursors of the rest of the foregut are recruited at later stages of gastrulation. Loss of Mixl1 function results in reduced recruitment of the definitive endoderm, and causes cells in the endoderm to remain stationary during gastrulation. The observation that the endoderm cells are inherently unable to move despite the expansion of the mesoderm in the Mixl1-null mutant suggests that the movement of the endoderm and the mesoderm is driven independently of one another.
Publisher
COMPANY OF BIOLOGISTS LTD
Keywords
GERM LAYER FORMATION; VISCERAL ENDODERM; PRIMITIVE-STREAK; CELL FATE; AUTORADIOGRAPHIC ANALYSIS; MORPHOGENETIC MOVEMENT; ANTEROPOSTERIOR AXIS; EPIBLAST CELLS; CHICK-EMBRYO; BODY PLAN
Publisher's Version
https://doi.org/10.1242/dev.02724
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2007-01-15 12:00:00
Last Modified: 0001-01-01 12:00:00
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