Optimization of TCR transgenic T cells for in vivo tracking of immune responses

Author(s): Stock, AT; Mueller, SN; Kleinert, LM; Heath, WR; Carbone, FR; Jones, CM;
Details: Publication Year 2007-07,Volume 85,Issue #5,Page 394-396
Journal Title: IMMUNOLOGY AND CELL BIOLOGY
Publication Type: Journal Article
Abstract: T-cell receptor (TCR) transgenic mice have proven useful for the study of various immune parameters. Despite this, it has been suggested that transferred T cells respond differently to their endogenous counterparts at least in terms of conversion to antigen-experienced populations bearing memory cell markers. Here, we have compared the response of TCR transgenic T cells to endogenous populations within the context of infection with herpes simplex virus. We found that adoptive transfer at numbers approaching those of the endogenous virus-specific subset results in a response with similar kinetics, magnitude and memory subset conversion. This suggests that this form of optimized T-cell transfer remains a useful means of tracking antiviral immune responses.
Publisher: NATURE PUBLISHING GROUP
Keywords: HERPES-SIMPLEX-VIRUS; PRECURSOR FREQUENCY; EFFECTOR FUNCTIONS; CUTTING EDGE; MEMORY CELLS; INFECTION; ACTIVATION; SUBSETS
Publisher's Version: https://doi.org/10.1038/sj.icb.7100076
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2007-07-01 12:00:00