Characterization of the opossum immune genome provides insights into the evolution of the mammalian immune system
- Author(s)
- Belov, K; Sanderson, CE; Deakin, JE; Wong, ESW; Assange, D; McColl, KA; Gout, A; de Bono, B; Barrow, AD; Speed, TP; Trowsdale, J; Papenfuss, AT;
- Details
- Publication Year 2007-07,Volume 17,Issue #7,Page 982-991
- Journal Title
- GENOME RESEARCH
- Publication Type
- Journal Article
- Abstract
- The availability of the first marsupial genome sequence has allowed us to characterize the immunome of the gray short-tailed opossum (Monodelphis domestica). Here we report the identification of key immune genes, including the highly divergent chemokines, defensins, cathelicidins, and Natural Killer cell receptors. It appears that the increase in complexity of the mammalian immune system occurred prior to the divergence of the marsupial and eutherian lineages similar to 180 million years ago. Genomes of ancestral mammals most likely contained all of the key mammalian immune gene families, with evolution on different continents, in the presence of different pathogens leading to lineage specific expansions and contractions, resulting in some minor differences in gene number and composition between different mammalian lineages. Gene expansion and extensive heterogeneity in opossum antimicrobial peptide genes may have evolved as a consequence of the newborn young needing to survive without an adaptive immune system in a pathogen laden environment. Given the similarities in the genomic architecture of the marsupial and eutherian immune systems, we propose that marsupials are ideal model organisms for the study of developmental immunology.
- Publisher
- COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
- Keywords
- MAJOR HISTOCOMPATIBILITY COMPLEX; MHC CLASS-I; MARSUPIAL MONODELPHIS-DOMESTICA; LEUKOCYTE RECEPTOR COMPLEX; ANCESTRAL REGION; GENE CLUSTERS; CHICKEN; FAMILY; DIVERSIFICATION; IDENTIFICATION
- Publisher's Version
- https://doi.org/10.1101/gr.6121807
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-07-01 12:00:00