Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences
Details
Publication Year 2007-05-10, Volume 447, Issue #7141, Page 167-177
Journal Title
NATURE
Publication Type
Journal Article
Abstract
We report a high-quality draft of the genome sequence of the grey, short-tailed opossum ( Monodelphis domestica). As the first metatherian ('marsupial') species to be sequenced, the opossum provides a unique perspective on the organization and evolution of mammalian genomes. Distinctive features of the opossum chromosomes provide support for recent theories about genome evolution and function, including a strong influence of biased gene conversion on nucleotide sequence composition, and a relationship between chromosomal characteristics and X chromosome inactivation. Comparison of opossum and eutherian genomes also reveals a sharp difference in evolutionary innovation between protein-coding and non-coding functional elements. True innovation in protein-coding genes seems to be relatively rare, with lineage-specific differences being largely due to diversification and rapid turnover in gene families involved in environmental interactions. In contrast, about 20% of eutherian conserved non-coding elements (CNEs) are recent inventions that postdate the divergence of Eutheria and Metatheria. A substantial proportion of these eutherian-specific CNEs arose from sequence inserted by transposable elements, pointing to transposons as a major creative force in the evolution of mammalian gene regulation.
Publisher
NATURE PUBLISHING GROUP
Keywords
X-CHROMOSOME INACTIVATION; SHORT-TAILED OPOSSUM; RECOMBINATION RATES; TRANSPOSABLE ELEMENTS; VERTEBRATE EVOLUTION; REGULATORY NETWORKS; MAMMALIAN EVOLUTION; MOBILE ELEMENTS; GENE DESERTS; MOUSE
WEHI Research Division(s)
Bioinformatics
Rights Notice
© 2013 Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.


Creation Date: 2007-05-10 12:00:00
Last Modified: 0001-01-01 12:00:00
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