Illuminating Plasmodium falciparum-infected red blood cell
- Author(s)
- Tilley, L; McFadden, G; Cowman, A; Klonis, N;
- Details
- Publication Year 2007-06,Volume 23,Issue #6,Page 268-277
- Journal Title
- TRENDS IN PARASITOLOGY
- Publication Type
- Journal Article
- Abstract
- The malaria parasite undergoes a remarkable series of morphological transformations, which underpin its life in both human and mosquito hosts. The advent of molecular transfection technology coupled with the ability to introduce fluorescent reporter proteins that faithfully track and expose the activities of parasite proteins has revolutionized our view of parasite cell biology. The greatest insights have been realized in the erythrocyte stages of Plasmodium falciparum. P. falciparum invades and remodels the human erythrocyte: it feeds on haemoglobin, grows and divides, and subverts the physiology of its hapless host. Fluorescent proteins have been employed to track and dissect each of these processes and have revealed details and exposed new paradigms.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- TRANSFECTED MALARIA PARASITES; HISTIDINE-RICH PROTEIN; MAURERS CLEFTS; TOXOPLASMA-GONDII; PARASITOPHOROUS VACUOLE; SECRETORY PATHWAY; HOST-CELL; APICOMPLEXAN PARASITES; ERYTHROCYTE INVASION; FLUORESCENT PROTEIN
- Publisher's Version
- https://doi.org/10.1016/j.pt.2007.04.001
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-06-01 12:00:00