A probabilistic view of immunology: Drawing parallels with physics
- Author(s)
- Hodgkin, PD;
- Details
- Publication Year 2007-06,Volume 85,Issue #4,Page 295-299
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Regulating the strength and class of an immune response requires lymphocytes to act as complex signal integrating 'machines', taking information from multiple sources while making decisions that affect the final outcome. Describing and understanding the decision-making behaviour of lymphocytes within the context of the dynamic multifaceted immune system appears immensely complicated. In this article I contrast two alternative frameworks, the deterministic and the probabilistic as competing paths to achieve successful quantitative immune models. As the two alternatives are traditional scientific rivals, I use the probabilistic fields in physics to highlight the potential value of the probabilistic perspective in immunology.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- T-CELLS; MECHANISM; PROLIFERATION; RESPONSES; CALCULUS; DIVISION
- Publisher's Version
- https://doi.org/10.1038/sj.icb.710061
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-06-01 12:00:00