The transcriptional regulation of B cell lineage commitment
Author(s)
Nutt, SL; Kee, BL;
Details
Publication Year 2007-06,Volume 26,Issue #6,Page 715-725
Journal Title
IMMUNITY
Publication Type
Journal Article
Abstract
The expression of lineage-associated genes, as well as the survival and expansion of committed B cell progenitors, is controlled by multiple transcriptional regulators and growth-factor receptors. Whereas certain DNA-binding proteins, such as lkaros and PU.1, are required primarily for the formation of more primitive lymphoid progenitors, other factors such as E2A and EBF1 have more direct roles in specifying the B cell-specific gene-expression program. Further, Pax5 functions to promote B cell commitment by repressing lineage-inappropriate gene expression and reinforcing B cell-specific gene expression. In this review, we focus on recent studies that have revealed that instead of a simple transcriptional hierarchy, efficient B cell commitment and differentiation requires the combinatorial activity of multiple transcription factors in a complex gene regulatory network.
Publisher
CELL PRESS
Keywords
COMMON LYMPHOID PROGENITORS; DNA-BINDING PROTEINS; INTERLEUKIN-7 RECEPTOR-ALPHA; HEMATOPOIETIC STEM-CELLS; MOUSE BONE-MARROW; GENE-EXPRESSION; DENDRITIC CELLS; FACTOR EBF; TARGETED DISRUPTION; MYELOID PROGENITOR
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2007-06-01 12:00:00
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