Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma
Details
Publication Year 2007-08,Volume 2,Issue #2,Page 130-138
Journal Title
CELL HOST & MICROBE
Publication Type
Journal Article
Abstract
Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variable antigen expressed by P. falciparurn, the malarial parasite. PfEMP-1, present on the surface of infected host erythrocytes, mediates erythrocyte binding to vascular enclothelium, enabling the parasite to avoid splenic clearance. In addition, PfEMP-1 is proposed to regulate host immune responses via interactions with the CD36 receptor on antigen-presenting cells. We investigated the immunoregulatory function of PfEMP-1 by comparing host cell responses to erythrocytes infected with either wild-type parasites or transgenic parasites lacking PfEMP-1. We showed that PfEMP-1 suppresses the production of the cytokine interferon-gamma by human peripheral blood mononuclear cells early after exposure to P. falciparum. Suppression of this rapid proinflammatory response was CD36 independent and specific to interferon-gamma production by gamma delta-T, NK, and alpha beta-T cells. These data demonstrate a parasite strategy for downregulating the proinflammatory interferon-gamma response and further establish transgenic parasites lacking PfEMP-1 as powerful tools for elucidating PfEMP-1 functions.
Publisher
CELL PRESS
Keywords
DELTA-T-CELLS; MURINE CEREBRAL MALARIA; NATURAL-KILLER-CELL; HUMAN NK CELLS; INFECTED ERYTHROCYTES; DENDRITIC CELLS; IFN-GAMMA; PROINFLAMMATORY RESPONSES; PARASITIZED ERYTHROCYTES; CROSS-REACTIVITY
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Creation Date: 2007-08-01 12:00:00
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