Plasmodium falciparum erythrocyte membrane protein-1 specifically suppresses early production of host interferon-gamma
- Author(s)
- D'Ombrain, MC; Voss, TS; Maier, AG; Pearce, JA; Hansen, DS; Cowman, AF; Schofield, L;
- Details
- Publication Year 2007-08,Volume 2,Issue #2,Page 130-138
- Journal Title
- CELL HOST & MICROBE
- Publication Type
- Journal Article
- Abstract
- Plasmodium falciparum erythrocyte membrane protein-1 (PfEMP-1) is a variable antigen expressed by P. falciparurn, the malarial parasite. PfEMP-1, present on the surface of infected host erythrocytes, mediates erythrocyte binding to vascular enclothelium, enabling the parasite to avoid splenic clearance. In addition, PfEMP-1 is proposed to regulate host immune responses via interactions with the CD36 receptor on antigen-presenting cells. We investigated the immunoregulatory function of PfEMP-1 by comparing host cell responses to erythrocytes infected with either wild-type parasites or transgenic parasites lacking PfEMP-1. We showed that PfEMP-1 suppresses the production of the cytokine interferon-gamma by human peripheral blood mononuclear cells early after exposure to P. falciparum. Suppression of this rapid proinflammatory response was CD36 independent and specific to interferon-gamma production by gamma delta-T, NK, and alpha beta-T cells. These data demonstrate a parasite strategy for downregulating the proinflammatory interferon-gamma response and further establish transgenic parasites lacking PfEMP-1 as powerful tools for elucidating PfEMP-1 functions.
- Publisher
- CELL PRESS
- Keywords
- DELTA-T-CELLS; MURINE CEREBRAL MALARIA; NATURAL-KILLER-CELL; HUMAN NK CELLS; INFECTED ERYTHROCYTES; DENDRITIC CELLS; IFN-GAMMA; PROINFLAMMATORY RESPONSES; PARASITIZED ERYTHROCYTES; CROSS-REACTIVITY
- Publisher's Version
- https://doi.org/10.1016/j.chom.2007.06.012
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-08-01 12:00:00