TCR affinity promotes CD8(+) T cell expansion by regulating survival
- Author(s)
- Hommel, M; Hodgkin, PD;
- Details
- Publication Year 2007-08-15,Volume 179,Issue #4,Page 2250-2260
- Journal Title
- JOURNAL OF IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- Ligation with high affinity ligands are known to induce T lymphocytes to become fully activated effector cells while ligation with low affinity ligands (or partial agonists) may result in a delayed or incomplete response. We have examined the quantitative features of CD8(+) T cell proliferation induced by peptides of different TCR affinities at a range of concentrations in the mouse OT-I model. Both the frequency of cells responding and the average time taken for cells to reach their first division are affected by peptide concentration and affinity. Consecutive division times, however, remained largely unaffected by these variables. Importantly, we identified affinity to be the sole regulator of cell death in subsequent division. These results suggest a mechanism whereby TCR affinity detection can modulate the subsequent rate of T cell growth and ensure the dominance of higher affinity clones over time.
- Publisher
- AMER ASSOC IMMUNOLOGISTS
- Keywords
- LYMPHOCYTE DIVISION; RECEPTOR ANTAGONISTS; POSITIVE SELECTION; CLONAL EXPANSION; IN-VITRO; PEPTIDE; LIGANDS; MODEL; REPERTOIRE; ACTIVATION
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-08-15 12:00:00