Microwave-assisted, zinc-mediated peptide coupling of N-benzyl-alpha,alpha-disubstituted amino acids
- Author(s)
- Cianci, J; Baell, JB; Harvey, AJ;
- Details
- Publication Year 2007-08-20,Volume 48,Issue #34,Page 5973-5975
- Journal Title
- TETRAHEDRON LETTERS
- Publication Type
- Journal Article
- Abstract
- Incorporation of the extremely hindered amino acid N-benzylaminoisobutyric acid into dipeptides under microwave irradiation with commercial zinc dust is described. A comparative survey of various methodologies for hindered peptide couplings was undertaken. The optimised coupling conditions were free from racemisation and applicable to other hindered amino acids. (c) 2007 Elsevier Ltd. All rights reserved.
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- HINDERED ALPHA,ALPHA-DIALKYL; EFFICIENT SYNTHESIS; CHLORIDES; PROTECTION; FLUORIDES; REAGENTS; BROMIDES; ESTERS; DUST
- Publisher's Version
- https://doi.org/10.1016/j.tetiet.2007.06.109
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-08-20 12:00:00