Coordinating TLR-activated signaling pathways in cells of the immune system
- Author(s)
- Banerjee, A; Gerondakis, S;
- Details
- Publication Year 2007-08,Volume 85,Issue #6,Page 420-424
- Journal Title
- IMMUNOLOGY AND CELL BIOLOGY
- Publication Type
- Journal Article
- Abstract
- Toll-like receptor (TLR) signaling leads to the activation of mitogen-activated protein kinase and nuclear factor-kappa B signaling pathways. While the upstream signaling events initiated at the level of adaptors and the activation of the downstream signaling pathways have received a lot of attention, our understanding of how these signaling pathways are coordinated to regulate gene expression is poorly understood. This review gives a selective overview on our current understanding of signaling downstream of TLRs, with an emphasis on how the upstream kinases like the mitogen-activated protein kinase kinase kinases (TAK1 and Tpl2) and inhibitor of kappa-B kinase (IKK) coordinate the signaling events that steer the course of an immune response.
- Publisher
- NATURE PUBLISHING GROUP
- Keywords
- NF-KAPPA-B; TOLL-LIKE RECEPTORS; ALPHA MESSENGER-RNA; PROTEIN-KINASE P38; AU-RICH ELEMENTS; CD4(+) T-CELLS; NF-KAPPA-B1 P105; MAP KINASE; ADAPTER MOLECULE; DENDRITIC CELLS
- Publisher's Version
- https://doi.org/10.1038/sj.icb.7100098
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-08-01 12:00:00