Outside looking in: the inner workings of the crosspresentation pathway within dendritic cells
- Author(s)
- Villadangos, JA; Heath, WR; Carbone, FR;
- Details
- Publication Year 2007-02,Volume 28,Issue #2,Page 45-47
- Journal Title
- TRENDS IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- The entry of exogenous antigen into the MHC class I-restricted crosspresentation pathway can contribute to CD8+ T cell tolerance and immunity, in particular to peripheral self-antigens or selected viruses and bacteria showing restricted tissue tropism. Dendritic cells are the key crosspresenting cells and, as such, they are thought to carry specialized machinery dedicated to this purpose. Two recent papers describe intracellular components tailored to the dendritic cell crosspresentation pathway.
- Publisher
- ELSEVIER SCI LTD
- Keywords
- CROSS-PRESENTATION; ENDOPLASMIC-RETICULUM; EXOGENOUS ANTIGENS; COMPARTMENT; PHAGOSOMES; MOLECULES; MECHANISM; IMMUNITY; CYTOSOL; INVIVO
- Publisher's Version
- https://doi.org/10.1016/j.it.2006.12.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-02-01 12:00:00