A role for neuropeptide Y (NPY) in phagocytosis: Implications for innate and adaptive immunity
- Author(s)
- Bedoui, S; von Horsten, S; Gebhardt, T;
- Details
- Publication Year 2007-02,Volume 28,Issue #2,Page 373-376
- Journal Title
- PEPTIDES
- Publication Type
- Journal Article
- Abstract
- Although it is broadly accepted that the immune system and the nervous system functionally interact with each other at various levels, many aspects of this crosstalk still remain unclear. One player in this interaction is neuropeptide Y (NPY), a sympathetic neurotransmitter, which has been demonstrated to regulate a broad variety of immune functions. in this review we will outline key findings on the effects NPY exerts on phagocytosis by neutrophils and monocytes/macrophages and its relevance to the elimination of invading pathogens. Furthermore, we will discuss the implications of these findings for antigen presentation by dendritic cells and the induction of adaptive immune responses. (c) 2007 Elsevier Inc. All rights reserved.
- Publisher
- ELSEVIER SCIENCE INC
- Keywords
- MACROPHAGE FUNCTIONS; DENDRITIC CELLS; PEPTIDE-YY; LEISHMANIA; EXPRESSION; RECEPTOR; SYSTEM
- Publisher's Version
- https://doi.org/10.1016/j.peptides.2006.07.029
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-02-01 12:00:00