Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8(+) T cell
- Author(s)
- Belz, GT; Zhang, L; Lay, MDH; Kupresanin, F; Davenport, MP;
- Details
- Publication Year 2007-04-10,Volume 104,Issue #15,Page 6341-6346
- Journal Title
- PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Publication Type
- Journal Article
- Abstract
- Antigen presentation within the lymph node draining a site of infection is crucial for initiation of cytotoxic T cell responses. Precisely how this antigen presentation regulates T cell expansion in vivo is unclear. Here, we show that, in primary infection, antigen presentation peaks -3 days postinfection and then slowly decays until day 12. This prolonged antigen presentation is required for optimal expansion of naive CD8(+) T cells, because early ablation of clendritic cells reduces the later CD8(+) T cell response. Antigen presentation during secondary infection was 10-fold lower in magnitude and largely terminated by day 4 postinfection. Expansion of memory, but not naive, antigen-specific T cells was tightly controlled by perforin-dependent cytolysis of antigen-presenting cells. The ability of the memory T cells to remove antigenpresenting cells provides a negative-feed back loop to directly limit the duration of antigen presentation in vivo.
- Publisher
- NATL ACAD SCIENCES
- Keywords
- HERPES-SIMPLEX-VIRUS; DENDRITIC CELLS; IN-VIVO; INFLUENZA-VIRUS; LYMPH-NODES; PROTECTIVE IMMUNITY; SELF-TOLERANCE; INFECTION; RESPONSES; DIFFERENTIATION
- Publisher's Version
- https://doi.org/10.1073/pnas.0609990104
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-04-10 12:00:00