Structural insights into the degradation of Mcl-1 induced by BH3 domains
Details
Publication Year 2007-04-10, Volume 104, Issue #15, Page 6217-6222
Journal Title
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Publication Type
Journal Article
Abstract
Apoptosis is held in check by prosurvival proteins of the Bcl-2 family. The distantly related BH3-only proteins bind to and antagonize them, thereby promoting apoptosis. Whereas binding of the BH3-only protein Noxa to prosurvival Mcl-1 induces Mcl-1 degradation by the proteasome, binding of another BH3-only ligand, Bim, elevates Mcl-1 protein levels. We compared the three-dimensional structures of the complexes formed between BH3 peptides of both Bim and Noxa, and we show that a discrete C-terminal sequence of the Noxa BH3 is necessary to instigate Mcl-1 degradation.
Publisher
NATL ACAD SCIENCES
Keywords
PROGRAMMED CELL-DEATH; BCL-2 FAMILY; BH3-ONLY PROTEINS; APOPTOSIS; SURVIVAL; COMPLEX; INHIBITOR; DIFFERENTIATION; MUTAGENESIS; LYMPHOCYTES
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2007-04-10 12:00:00
Last Modified: 0001-01-01 12:00:00
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