Modifiers of epigenetic reprogramming show paternal effects in the mouse

Author(s): Chong, SY; Vickaryous, N; Ashe, A; Zamudio, N; Youngson, N; Hemley, S; Stopka, T; Skoultchi, A; Matthews, J; Scott, HS; de Kretser, D; O'Bryan, M; Blewitt, M; Whitelaw, E;
Details: Publication Year 2007-05,Volume 39,Issue #5,Page 614-622
Journal Title: NATURE GENETICS
Publication Type: Journal Article
Abstract: There is increasing evidence that epigenetic information can be inherited across generations in mammals, despite extensive reprogramming both in the gametes and in the early developing embryo. One corollary to this is that disrupting the establishment of epigenetic state in the gametes of a parent, as a result of heterozygosity for mutations in genes involved in reprogramming, could affect the phenotype of offspring that do not inherit the mutant allele. Here we show that such effects do occur following paternal inheritance in the mouse. We detected changes to transcription and chromosome ploidy in adult animals. Paternal effects of this type have not been reported previously in mammals and suggest that the untransmitted genotype of male parents can influence the phenotype of their offspring.
Publisher: NATURE PUBLISHING GROUP
Keywords: POSITION EFFECT VARIEGATION; SMALL RNAS; EMBRYONIC-DEVELOPMENT; METHYLATION IMPRINTS; AGOUTI LOCUS; GERM-CELLS; INHERITANCE; GENE; MICE; EXPRESSION
Publisher's Version: https://doi.org/10.1038/ng2031
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2007-05-01 12:00:00