Rational approaches to developing an anti-disease vaccine against malaria

Author(s): Schofield, L;
Details: Publication Year 2007-05,Volume 9,Issue #6,Page 784-791
Journal Title: MICROBES AND INFECTION
Publication Type: Journal Article
Abstract: Vaccination against pathogen toxins provides a rational approach to prevent morbidity and mortality, and is widely validated in the context of bacterial infections. A saccharide-conjugate vaccine targeting the malaria glycosylphosphatidylinositol toxin glycan could therefore prevent severe disease. This strategy could also reduce the risk posed by 'rebound' infections or immunopathology associated with other interventions. (C) 2007 Elsevier Masson SAS. All rights reserved.
Publisher: ELSEVIER SCIENCE BV
Keywords: VASCULAR ENDOTHELIAL-CELLS; PLASMODIUM-FALCIPARUM; GLYCOSYLPHOSPHATIDYLINOSITOL TOXIN; T-CELLS; UNINFECTED ERYTHROCYTES; SIGNAL-TRANSDUCTION; PARASITE; ANEMIA; IMMUNITY; RESPONSES
Publisher's Version: https://doi.org/10.1016/j.micinf.2007.02.010
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2007-05-01 12:00:00