Terminal differentiation of lymphocytes depends on Blimp-1
- Author(s)
- Kallies, A; Nutt, SL;
- Details
- Publication Year 2007-04,Volume 19,Issue #2,Page 156-162
- Journal Title
- CURRENT OPINION IN IMMUNOLOGY
- Publication Type
- Journal Article
- Abstract
- B lymphocyte induced maturation protein 1 (Blimp-1) has long been considered a master regulator of the terminal differentiation of B cells into anti body-secretin g plasma cells. Gene-targeting experiments have now demonstrated that quantitative changes in Blimp-1 expression define plasma cell ontogeny - a process that requires the continual function of Blimp-1. Recently, new roles for Blimp-1 have been revealed, as a suppressor of diffuse large B cell lymphoma and as a key regulator of T-cell differentiation. Blimp-1 is expressed in differentiated effector T cells and controls their homeostasis. These new findings suggest that Blimp-1 has a conserved function in the final differentiation of both the cellular and the humoral arm of the adaptive immune response.
- Publisher
- CURRENT BIOLOGY LTD
- Keywords
- PLASMA-CELL DIFFERENTIATION; MEMORY B-CELLS; TRANSCRIPTIONAL REPRESSOR BLIMP-1; CLASS-SWITCH RECOMBINATION; GENE-EXPRESSION; T-CELLS; SECRETING CELLS; GERM-CELLS; C-MYC; MATURATION
- Publisher's Version
- https://doi.org/10.1016/j.coi.2007.01.003
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2007-04-01 12:00:00