JAK1 Takes a FERM Hold of Type II Cytokine Receptors
- Author(s)
- Babon, JJ; Liau, NP; Kershaw, NJ;
- Details
- Publication Year 2016-06-07,Volume 24,Issue #6,Page 840-2
- Journal Title
- Structure
- Publication Type
- Journal Article
- Abstract
- Janus kinases (JAKs) initiate the intracellular signaling cascade triggered by exposure of cells to cytokines and interferons. In order to achieve this, JAKs are bound to the intracellular domain of specific cytokine receptors immediately adjacent to the cell membrane. In this issue of Structure, Ferrao et al. (2016) provide structural details of such an interaction and in doing so, identify for the first time the motif used by type II cytokine receptors to recruit JAK1.
- Publisher
- Cell Press
- Research Division(s)
- Cancer And Haematology; Structural Biology
- PubMed ID
- 27276423
- Publisher's Version
- https://doi.org/10.1016/j.str.2016.05.007
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-06-16 12:25:09
Last Modified: 2017-08-21 10:21:40