Dynamic changes in Id3 and E-protein activity orchestrate germinal center and plasma cell development
- Gloury, R; Zotos, D; Zuidscherwoude, M; Masson, F; Liao, Y; Hasbold, J; Corcoran, LM; Hodgkin, PD; Belz, GT; Shi, W; Nutt, SL; Tarlinton, DM; Kallies, A;
Publication Year 2016-05-30, Volume 213, Issue #6, Page 1095-111
- Journal Title
- J Exp Med
- Publication Type
- Journal Article
- The generation of high-affinity antibodies requires germinal center (GC) development and differentiation of long-lived plasma cells in a multilayered process that is tightly controlled by the activity of multiple transcription factors. Here, we reveal a new layer of complexity by demonstrating that dynamic changes in Id3 and E-protein activity govern both GC and plasma cell differentiation. We show that down-regulation of Id3 in B cells is essential for releasing E2A and E2-2, which in a redundant manner are required for antigen-induced B cell differentiation. We demonstrate that this pathway controls the expression of multiple key factors, including Blimp1, Xbp1, and CXCR4, and is therefore critical for establishing the transcriptional network that controls GC B cell and plasma cell differentiation.
- WEHI Research Division(s)
- Molecular Immunology; Bioinformatics; Immunology
- PubMed ID
- Publisher's Version
- Rights Notice
- This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org.ezp.lib.unimelb.edu.au/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
Creation Date: 2016-06-16 10:27:05Last Modified: 2016-06-16 11:32:48