Population genomics studies identify signatures of global dispersal and drug resistance in Plasmodium vivax

Hupalo, DN; Luo, Z; Melnikov, A; Sutton, PL; Rogov, P; Escalante, A; Vallejo, AF; Herrera, S; Arevalo-Herrera, M; Fan, Q; Wang, Y; Cui, L; LUCAS, CM; Durand, S; Sanchez, JF; Baldeviano, GC; Lescano, AG; Laman, M; Barnadas, C; Barry, A; Mueller, I; Kazura, JW; Eapen, A; Kanagaraj, D; Valecha, N; Ferreira, MU; Roobsoong, W; Nguitragool, W; Sattabonkot, J; Gamboa, D; Kosek, M; Vinetz, JM; Gonzalez-Ceron, L; Birren, BW; Neafsey, DE; Carlton, JM

Author(s): Hupalo, DN; Luo, Z; Melnikov, A; Sutton, PL; Rogov, P; Escalante, A; Vallejo, AF; Herrera, S; Arevalo-Herrera, M; Fan, Q; Wang, Y; Cui, L; LUCAS, CM; Durand, S; Sanchez, JF; Baldeviano, GC; Lescano, AG; Laman, M; Barnadas, C; Barry, A; Mueller, I; Kazura, JW; Eapen, A; Kanagaraj, D; Valecha, N; Ferreira, MU; Roobsoong, W; Nguitragool, W; Sattabonkot, J; Gamboa, D; Kosek, M; Vinetz, JM; Gonzalez-Ceron, L; Birren, BW; Neafsey, DE; Carlton, JM;
Details: Publication Year 2016-06-27,Volume 48,Issue #8,Page 953-8
Journal Title: Nat Genet
Publication Type: Journal Article
Abstract: Plasmodium vivax is a major public health burden, responsible for the majority of malaria infections outside Africa. We explored the impact of demographic history and selective pressures on the P. vivax genome by sequencing 182 clinical isolates sampled from 11 countries across the globe, using hybrid selection to overcome human DNA contamination. We confirmed previous reports of high genomic diversity in P. vivax relative to the more virulent Plasmodium falciparum species; regional populations of P. vivax exhibited greater diversity than the global P. falciparum population, indicating a large and/or stable population. Signals of natural selection suggest that P. vivax is evolving in response to antimalarial drugs and is adapting to regional differences in the human host and the mosquito vector. These findings underline the variable epidemiology of this parasite species and highlight the breadth of approaches that may be required to eliminate P. vivax globally.
Publisher: NPG
Research Division(s): Infection And Immunity; Population Health And Immunity
PubMed ID: 27348298
Link To PubMed Central Version: https://www-ncbi-nlm-nih-gov/pmc/articles/PMC5347536/
Publisher's Version: https://doi.org/10.1038/ng.3588
NHMRC Grants: NHMRC/1043345,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2016-08-09 12:01:46

Last Modified: 2017-09-11 11:55:31