Small molecules targeting Mcl-1: the search for a silver bullet in cancer therapy
- Author(s)
- Nhu, Duong; Lessene, Guillaume; Huang, David CS; Burns, Christopher J;
- Details
- Publication Year 2016,Volume 7,Issue #5,Page 778-787
- Journal Title
- MedChemComm
- Publication Type
- Journal Article
- Abstract
- Mcl-1 (myeloid-cell-leukemia-sequence-1) is a pro-survival member of the Bcl-2 family of proteins. Mcl-1 has been shown to be critical to the survival of a variety of cancer cells and to mediate resistance to conventional and targeted chemotherapeutics. Whilst potent and selective small molecule inhibitors of Bcl-2 and Bcl-XL have been developed, the discovery of selective inhibitors of Mcl-1 has proven more problematic and only very recently have potent and selective inhibitors been described. In this review we outline key features of Mcl-1 biology, and chemical approaches and outcomes of inhibiting this important survival protein for the treatment of cancers.
- Publisher
- The Royal Society of Chemistry
- Research Division(s)
- Chemical Biology; Cancer And Haematology
- PubMed ID
- 24677741
- Publisher's Version
- https://doi.org/10.1039/C5MD00582E
- NHMRC Grants
- NHMRC/1057742,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-08-09 12:01:45
Last Modified: 2018-03-20 03:31:00