Regulation of platelet lifespan in the presence and absence of TPO signaling
Publication Year 2016-06-25, Volume 14, Issue #9, Page 1882-7
Journal Title
Journal of Thrombosis and Haemostasis
Publication Type
Journal Article
BACKGROUND: It is well established that thrombopoietin (TPO), acting via its receptor Mpl, is the major cytokine regulator of platelet biogenesis. The primary mechanism by which TPO signaling stimulates thrombopoiesis is via stimulation of Mpl-expressing hematopoietic progenitors; Mpl on megakaryocytes and platelets act to control the amount of TPO available. TPO could potentially reduce platelet and/or megakaryocyte apoptosis and therefore increase the platelet count. However, the effect of TPO receptor signaling on platelet survival is unresolved. METHODS AND RESULTS: Here, we investigated platelet survival in mouse models of absent or enhanced TPO signaling. In the absence of thrombocytopenia, Mpl deficiency did not negatively influence platelet lifespan, nor was platelet survival affected in transgenic mice with chronically increased TPO signaling. CONCLUSIONS: We conclude that TPO and its receptor Mpl are dispensable for platelet survival in adult mice. This article is protected by copyright. All rights reserved.
WEHI Research Division(s)
Immunology; Cancer And Haematology; Chemical Biology
PubMed ID
Publisher's Version
Rights Notice
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Creation Date: 2016-08-09 12:01:45
Last Modified: 2018-07-11 09:34:55
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