Th17 cell differentiation proceeds independently of IRF8
- Author(s)
- Newman, DM; Leung, PS; Putoczki, TL; Nutt, SL; Cretney, E;
- Journal Title
- Immunol Cell Biol
- Publication Type
- Journal Article in press
- Abstract
- The transcriptional repressor/activator interferon regulatory factor 8 (IRF8) modulates the differentiation of a multitude of hematopoietic lineages. However, the role of IRF8 in CD4+ T-cell development is less well defined, with a recent study implicating IRF8 as an intrinsic repressor of interleukin-17 (IL-17) expressing T helper type 17 (Th17) cell differentiation. Using an IRF8-EGFP reporter strain we have confirmed that IRF8 is expressed in all T helper lineages, including Th17 cells. The loss of IRF8 did not affect Th17 differentiation in vitro, beyond a small increase in IL-22 expression. Moreover, IRF8 deficiency did not enhance the Th17 immune response in experimental T-cell transfer colitis. Together, these results suggest that IRF8 does not play an essential intrinsic role in Th17 cell differentiation.Immunology and Cell Biology advance online publication, 3 May 2016; doi:10.1038/icb.2016.33.
- Publisher
- NPG
- Research Division(s)
- Inflammation; Molecular Immunology
- PubMed ID
- 27140932
- Publisher's Version
- https://doi.org/10.1038/icb.2016.33
- NHMRC Grants
- NHMRC/1054925, NHMRC/1047313,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-06-15 08:01:03
Last Modified: 2016-06-15 08:07:55