Heterogeneity, functional specialization and differentiation of monocyte derived dendritic cells
- Author(s)
- Chow, KV; Sutherland, RM; Zhan, Y; Lew, AM;
- Details
- Publication Year 2017,Volume 95,Issue #3,Page 244-251
- Journal Title
- Immunology and Cell Biology
- Publication Type
- Journal Article
- Abstract
- Dendritic cells (DCs) are professional antigen presenting cells that consist of functionally and phenotypically heterogeneous populations. Monocyte derived dendritic cells (moDCs) are a DC subset that have been attracting increasing interest due to their potent influence on adaptive immune function and their rapid accumulation upon an inflammatory stimulus. Whilst early studies on moDCs mainly addressed infection, their emergence and function in other settings such as autoimmunity and allogeneic organ transplantation are now being increasingly appreciated. In this review, the relationship between murine monocyte subsets and the moDCs that arise from them is discussed. Their role in initiating and modulating innate and adaptive immune responses in various pathophysiological scenarios is also explored, including how they may separate their labour from conventional DCs. How these findings might relate to their human counterparts is also discussed. Overall, monocytes and moDCs exhibit complex and heterogeneous behaviours that are critical in responses against microbial invasion, autoimmunity and allograft rejection.Immunology and Cell Biology accepted article preview online, 17 October 2016. doi:10.1038/icb.2016.104.
- Publisher
- Springer Nature
- Research Division(s)
- Immunology
- PubMed ID
- 27748730
- Publisher's Version
- https://doi.org/10.1038/icb.2016.104
- NHMRC Grants
- NHMRC/1037321, NHMRC/1043414, NHMRC/1080321, NHMRC/1105209,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-10-19 11:52:26
Last Modified: 2018-07-05 03:50:44