Haemopedia: an expression atlas of murine hematopoietic cells

de Graaf, CA; Choi, J; Baldwin, TM; Bolden, JE; Fairfax, KA; Robinson, AJ; Biben, C; Morgan, C; Ramsay, K; Ng, AP; Kauppi, M; Kruse, EA; Sargeant, TJ; Seidenman, N; D&#39;Amico, A; D&#39;Ombrain, MC; Lucas, EC; Koernig, S; Baz Morelli, A; Wilson, MJ; Dower, SK; Williams, B; Heazlewood, SY; Hu, Y; Nilsson, SK; Wu, L; Smyth, GK; Alexander, WS; Hilton, DJ

Author(s): de Graaf, CA; Choi, J; Baldwin, TM; Bolden, JE; Fairfax, KA; Robinson, AJ; Biben, C; Morgan, C; Ramsay, K; Ng, AP; Kauppi, M; Kruse, EA; Sargeant, TJ; Seidenman, N; D'Amico, A; D'Ombrain, MC; Lucas, EC; Koernig, S; Baz Morelli, A; Wilson, MJ; Dower, SK; Williams, B; Heazlewood, SY; Hu, Y; Nilsson, SK; Wu, L; Smyth, GK; Alexander, WS; Hilton, DJ;
Details: Publication Year 2016-08-03,Volume 7,Issue #3,Page 571-582
Journal Title: Stem Cell Reports
Publication Type: Journal Article
Abstract: Hematopoiesis is a multistage process involving the differentiation of stem and progenitor cells into distinct mature cell lineages. Here we present Haemopedia, an atlas of murine gene-expression data containing 54 hematopoietic cell types, covering all the mature lineages in hematopoiesis. We include rare cell populations such as eosinophils, mast cells, basophils, and megakaryocytes, and a broad collection of progenitor and stem cells. We show that lineage branching and maturation during hematopoiesis can be reconstructed using the expression patterns of small sets of genes. We also have identified genes with enriched expression in each of the mature blood cell lineages, many of which show conserved lineage-enriched expression in human hematopoiesis. We have created an online web portal called Haemosphere to make analyses of Haemopedia and other blood cell transcriptional datasets easier. This resource provides simple tools to interrogate gene-expression-based relationships between hematopoietic cell types and genes of interest.
Publisher: Cell Press
Research Division(s): Immunology; Molecular Immunology; Bioinformatics; Cancer And Haematology; Molecular Medicine
PubMed ID: 27499199
Publisher's Version: https://doi.org/10.1016/j.stemcr.2016.07.007
Open Access at Publisher's Site: https://doi.org/10.1016/j.stemcr.2016.07.007
NHMRC Grants: NHMRC/1016647, NHMRC/1048087, NHMRC/1054618, NHMRC/1058344, NHMRC/1058892,
Terms of Use/Rights Notice: Refer to copyright notice on published article.

Creation Date: 2016-08-10 04:12:52

Last Modified: 2018-07-11 09:21:37