Blimp-1 controls plasma cell function through the regulation of immunoglobulin secretion and the unfolded protein response
- Author(s)
- Tellier, J; Shi, W; Minnich, M; Liao, Y; Crawford, S; Smyth, GK; Kallies, A; Busslinger, M; Nutt, SL;
- Details
- Publication Year 2016-03,Volume 17,Issue #3,Page 323-30
- Journal Title
- Nat Immunol
- Publication Type
- Journal Article
- Abstract
- Plasma cell differentiation requires silencing of B cell transcription, while it establishes antibody-secretory function and long-term survival. The transcription factors Blimp-1 and IRF4 are essential for the generation of plasma cells; however, their function in mature plasma cells has remained elusive. We found that while IRF4 was essential for the survival of plasma cells, Blimp-1 was dispensable for this. Blimp-1-deficient plasma cells retained their transcriptional identity but lost the ability to secrete antibody. Blimp-1 regulated many components of the unfolded protein response (UPR), including XBP-1 and ATF6. The overlap in the functions of Blimp-1 and XBP-1 was restricted to that response, with Blimp-1 uniquely regulating activity of the kinase mTOR and the size of plasma cells. Thus, Blimp-1 was required for the unique physiological ability of plasma cells that enables the secretion of protective antibody.
- Publisher
- NPG
- Research Division(s)
- Molecular Immunology; Bioinformatics
- PubMed ID
- 26779600
- Link To PubMed Central Version
- https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4757736/
- Publisher's Version
- https://doi.org/10.1038/ni.3348
- NHMRC Grants
- NHMRC/361646, NHMRC/575500, NHMRC/1054925, NHMRC/1054618, NHMRC/1023454, NHMRC/1049416,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-29 11:46:11
Last Modified: 2018-03-07 02:46:23