Two roads to death – Bax targets mitochondria by distinct routes before or during apoptotic cell death
Author(s)
Dewson, Grant;
Details
Publication Year 2015-01-02,Volume 2,Issue #1,Page e974460
Journal Title
Mol Cell Oncol
Publication Type
Journal Article
Abstract
Recent studies have revolutionized our understanding of how the crucial apoptosis effectors Bax and Bak target mitochondria to kill cells. We recently reported that an important determinant of the localization, oligomerization, and apoptotic function of Bax is an interaction with either mitochondrial voltage-dependent anion channel 2 (VDAC2) (in healthy cells) or Bak (in apoptotic cells).1
Publisher
Taylor & Francis
Research Division(s)
Cell Signalling And Cell Death
NHMRC Grants
NHMRC/637335
ARC Grants
ARC/FT100100791,
Terms of Use/Rights Notice
Refer to copyright notice on published article.


Creation Date: 2016-02-17 04:20:08
Last Modified: 2016-02-17 04:25:45
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