In vivo at last. Demonstrating the biological credentials and clinical potential of GM-CSF
- Author(s)
- Alexander, WS;
- Details
- Publication Year 2016-01-30,Volume 44,Issue #8,Page 669-673
- Journal Title
- Experimental Hematology
- Publication Type
- Journal Article
- Abstract
- The pioneering contribution of Professor Donald Metcalf, who passed away in 2014, to the discovery and characterisation of the colony stimulating factors (CSFs) is exemplified by a seminal contribution to Experimental Haematology by Metcalf and colleagues that detailed the in vivo actions of the newly available recombinant granulocyte-macrophage colony-stimulating factor (GM-CSF) in 1987. The results described in this publication promoted GM-CSF actions from fascinating in vitro laboratory phenomena to the recognition that this cytokine was a genuine in vivo regulator of blood cell production and function and provided significant impetus for the clinical development of GM-CSF.
- Publisher
- Elsevier
- Research Division(s)
- Cancer And Haematology
- PubMed ID
- 26835837
- Publisher's Version
- https://doi.org/10.1016/j.exphem.2016.01.006
- NHMRC Grants
- NHMRC/1058344, NHMRC/1016647, NHMRC/1062840,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-03-14 03:05:28
Last Modified: 2018-07-05 03:43:13