Acquisition and longevity of antibodies to Plasmodium vivax pre-erythrocytic antigens in Western Thailand
- Author(s)
- Longley, RJ; Reyes-Sandoval, A; Montoya-Diaz, E; Dunachie, S; Kumpitak, C; Nguitragool, W; Mueller, I; Sattabongkot, J;
- Details
- Publication Year 2015-12-09,Volume 93,Issue #2,Page 117-124
- Journal Title
- Clin Vaccine Immunol
- Publication Type
- Journal Article
- Abstract
- Plasmodium vivax (Pv) is now the dominant Plasmodium species causing malaria in Thailand, yet little is known about naturally acquired immune responses to this parasite in this low-transmission region. The pre-erythrocytic stage of the Pv life cycle is considered an excellent target for a malaria vaccine, and in this study we assessed the stability of both the seropositivity and the magnitude of IgG responses to three different pre-erythrocytic Pv proteins in two groups of adults from an endemic region of western Thailand. These individuals were enrolled in a yearlong cohort study, and comprised one group whom remained Pv-free (by qPCR detection, n = 31) and another which experienced two or more blood-stage Pv infections during the year of follow up (n = 31). Despite overall low levels of seropositivity, both IgG positivity and magnitude was long-lived over the one-year period in the absence of qPCR-detectable blood-stage Pv infections. In contrast, in the adults with two or more Pv infections during the year, IgG positivity was maintained but the magnitude of the response to Pv CSP210 decreased over time. These findings demonstrate that long-term humoral immunity can develop in low-transmission regions.
- Publisher
- ASM
- Research Division(s)
- Population Health And Immunity
- PubMed ID
- 26656115
- Publisher's Version
- https://doi.org/10.1128/CVI.00501-15
- Open Access at Publisher's Site
http://cvi.asm.org/content/early/2015/12/07/CVI.00501-15.long- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-13 02:34:09
Last Modified: 2019-04-01 09:05:32