Current questions and possible controversies in autophagy
- Author(s)
- Lindqvist, LM; Simon, AK; Baehrecke, EH;
- Journal Title
- Cell Death Discov
- Publication Type
- Journal Article
- Abstract
- Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.
- Publisher
- NPG
- Research Division(s)
- Cell Signalling And Cell Death
- PubMed ID
- 26682061
- Publisher's Version
- https://doi.org/10.1038/cddiscovery.2015.36
- Open Access at Publisher's Site
http://www.nature.com/articles/cddiscovery201536- NHMRC Grants
- NHMRC/1035502,
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-13 02:34:09
Last Modified: 2016-01-13 03:13:18