Current questions and possible controversies in autophagy
Journal Title
Cell Death Discov
Publication Type
Journal Article
Abstract
Interest in autophagy has exploded over the last decade, with publications highlighting crosstalk with several other cellular processes including secretion, endocytosis, and cell suicide pathways including apoptosis. Autophagy proteins have also been implicated in other cellular processes independently of their roles in autophagy, creating complexities in the interpretation of autophagy (Atg) mutant gene data. Interestingly, this self-eating process is a survival mechanism that can also promote cell death, but when and how autophagy may 'switch' its function is still under debate. Indeed, there are currently many models of how autophagy actually influences cell death. In this review, we highlight some outstanding questions and possible controversies in the autophagy field.
Publisher
NPG
WEHI Research Division(s)
Cell Signalling And Cell Death
PubMed ID
26682061
Open Access at Publisher's Site
http://www.nature.com/articles/cddiscovery201536
NHMRC Grants
NHMRC/1035502
Rights Notice
Refer to copyright notice on published article.


Creation Date: 2016-01-13 02:34:09
Last Modified: 2016-01-13 03:13:18
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