Innate lymphoid cells: parallel checkpoints and coordinate interactions with T cells
- Author(s)
- Huntington, ND; Carpentier, S; Vivier, E; Belz, GT;
- Journal Title
- Curr Opin Immunol
- Publication Type
- Journal Article
- Abstract
- Protection of epithelial and mucosal surfaces is required for survival. The recent discovery of a diverse array of innate lymphoid cells that lie immediately beneath these surfaces has unexpectedly uncovered an entire defense system distinct from the adaptive system essential to protect these barriers. This multilayered design provides a robust system through coupling of two highly complementary networks to ensure immune protection. Here, we discuss the similarities in the hardwiring and diversification of innate lymphoid cells and T cells during mammalian immune responses.
- Publisher
- Elsevier
- Research Division(s)
- Molecular Immunology
- PubMed ID
- 26736074
- Publisher's Version
- https://doi.org/10.1016/j.coi.2015.11.008
- Terms of Use/Rights Notice
- Refer to copyright notice on published article.
Creation Date: 2016-01-13 02:34:08
Last Modified: 2016-01-13 03:05:21